Three pets (Chance, a young dog unfamiliar with the world; Shadow, an aging, wise dog; and Sassy, a snobby cat) are left behind when their family goes on vacation. Unsure of what happened, the animals set out on a quest to find their family. This journey across America is very dangerous and the animals risk never seeing their masters again. The group of pets travel across forested mountains and areas of wide-open countryside, while their family searches for them in the same areas.

Shadow, Sassy and Chance are back! It's been three years since their trek through the woods and over the mountains. Now the family lives in San Fransisco and they're taking a vacation in Canada. Only problem, the pets escape from the airport while being put in the cargo area of the plane. Now their family is in Canada and the pets are all alone in San Fransisco. They meet scruffy bully dogs and a gang of rebel dogs all abandoned and have started their own group. Also looking for them is a "Blood Red Van" driven by bumbling dog catchers. Also Chance meets a girl dog and it's love at first bite.

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